CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs-Reference-Cited by-同舟云学术

CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs

Published:2014-07-31 Issue:5 Volume:124 Page:750-760
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Jitschin Regina¹,Braun Martina¹,Büttner Maike²,Dettmer-Wilde Katja³,Bricks Juliane¹,Berger Jana¹,Eckart Michael J.⁴,Krause Stefan W.¹,Oefner Peter J.³,Le Blanc Katarina⁵,Mackensen Andreas¹,Mougiakakos Dimitrios¹

Affiliation:

1. Department of Internal Medicine 5, Hematology and Oncology, and

2. Institute of Pathology, Department of Nephropathology, University of Erlangen-Nuremberg, Erlangen, Germany;

3. Institute of Functional Genomics, University of Regensburg, Regensburg, Germany;

4. Onkologische Schwerpunktpraxis, Erlangen, Germany; and

5. Department of Medicine, Hematology Centre, Karolinska University Hospital, Stockholm, Sweden

Abstract

Key Points Monocytic IDOhi MDSCs are increased in CLL patients, suppress T cells, and promote TReg induction. CLL cells induce conversion of monocytes into MDSCs suggesting bidirectional crosstalk between CLL cells, MDSCs, and TRegs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/5/750/541661/750.pdf

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