The relationship between tissue factor and cancer progression: insights from bench and bedside

Author:

van den Berg Yascha W.1,Osanto Susanne2,Reitsma Pieter H.1,Versteeg Henri H.12

Affiliation:

1. Departments of Thrombosis and Hemostasis and

2. Clinical Oncology, Einthoven Laboratory for Experimental Vascular Medicine, Leiden Univerisity Medical Center, Leiden, The Netherlands

Abstract

AbstractIt is now widely recognized that a strong correlation exists between cancer and aberrant hemostasis. Patients with various types of cancers, including pancreatic, colorectal, and gastric cancer, often develop thrombosis, a phenomenon commonly referred to as Trousseau syndrome. Reciprocally, components from the coagulation cascade also influence cancer progression. The primary initiator of coagulation, the transmembrane receptor tissue factor (TF), has gained considerable attention as a determinant of tumor progression. On complex formation with its ligand, coagulation factor VIIa, TF influences protease-activated receptor-dependent tumor cell behavior, and regulates integrin function, which facilitate tumor angiogenesis both in vitro and in mouse models. Furthermore, evidence exists that an alternatively spliced isoform of TF also affects tumor growth and tumor angiogenesis. In patient material, TF expression and TF cytoplasmic domain phosphorylation correlate with disease outcome in many, but not in all, cancer subtypes, suggesting that TF-dependent signal transduction events are a potential target for therapeutic intervention in selected types of cancer. In this review, we summarize our current understanding of the role of TF in tumor growth and metastasis, and speculate on anticancer therapy by targeting TF.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference99 articles.

1. The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling?;Versteeg;Thromb Haemost,2001

2. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease.;Contrino;Nat Med,1996

3. Microparticles in cancer.;Rak;Semin Thromb Hemost,2010

4. Emerging insights in tissue factor-dependent signaling events.;Versteeg;Semin Thromb Hemost,2006

5. Alternatively spliced tissue factor induces angiogenesis through integrin ligation.;van den Berg;Proc Natl Acad Sci U S A,2009

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3