Affiliation:
1. From the Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan.
Abstract
Interleukin-25 (IL-25) is a recently described T helper 2 (TH2) cell–derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non–T-cell population. Here, we show that mast cells are also potent IL-25–producing cells. When bone marrow–derived mast cells were stimulated by immunoglobulin E cross-linking, IL-25 mRNA was induced within 30 minutes in a calcineurin-dependent manner, and the levels of IL-25 mRNA were comparable with those of activated TH2 cells. Production of IL-25 by mast cells was also detected at protein levels by immunoblotting. These results suggest that mast cells may enhance TH2-type immune response by producing IL-25.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Reference13 articles.
1. IL-17: prototype member of an emerging cytokine family.;Aggarwal;J Leukoc Biol.,2002
2. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25.;Hurst;J Immunol.,2002
3. Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice.;Pan;J Immunol.,2001
4. IL-25, a novel molecule that induces IL-4, IL-5 and IL-13 and Th2-associated pathologies in vivo.;Fort;Immunity.,2001
5. IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines.;Schwarzenberger;J Immunol.,1998
Cited by
208 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献