DC-SIGN–expressing macrophages trigger activation of mannosylated IgM B-cell receptor in follicular lymphoma-Reference-Cited by-同舟云学术

DC-SIGN–expressing macrophages trigger activation of mannosylated IgM B-cell receptor in follicular lymphoma

Published:2015-10-15 Issue:16 Volume:126 Page:1911-1920
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Amin Rada¹²³,Mourcin Frédéric¹²³,Uhel Fabrice¹⁴,Pangault Céline¹²³⁵,Ruminy Philippe⁶,Dupré Loic⁷⁸,Guirriec Marion¹²³,Marchand Tony¹²³⁹,Fest Thierry¹²³⁵,Lamy Thierry¹²³⁹,Tarte Karin¹²³⁵^ORCID

Affiliation:

1. Equipe Labellisée Ligue Contre le Cancer, Unité Mixte de Recherche U917, INSERM, Rennes, France;

2. Université Rennes 1, Unité Mixte de Recherche U917, Rennes, France;

3. Etablissement Français du Sang Bretagne, Rennes, France;

4. Service de réanimation médicale, Centre Hospitalier Universitaire de Rennes, Rennes, France;

5. Pôle Biologie, Centre Hospitalier Universitaire de Rennes, Rennes, France;

6. Centre Henri Becquerel, Université de Rouen, Unité Mixte de Recherche U918, INSERM, Rouen, France;

7. Université Toulouse III Paul-Sabatier, Toulouse, France;

8. Centre de Physiopathologie de Toulouse Purpan, Unité Mixte de Recherche 1043, INSERM, Toulouse, France; and

9. Service d’Hématologie Clinique, Centre Hospitalier Universitaire de Rennes, Rennes, France

Abstract

Key Points IgM+ FL B cells display a stronger BCR response than their GC B-cell counterpart despite significant BCR-related phosphatase activity. M2 macrophages trigger DC-SIGN–dependent cell adhesion and BCR activation in IgM+ FL B cells with a highly mannosylated BCR.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/16/1911/1389397/1911.pdf

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5. Emergence of idiotype variants during treatment of B-cell lymphoma with anti-idiotype antibodies.;Meeker;N Engl J Med,1985

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