Hypoxia-reperfusion affects osteogenic lineage and promotes sickle cell bone disease-Reference-Cited by-同舟云学术

Hypoxia-reperfusion affects osteogenic lineage and promotes sickle cell bone disease

Published:2015-11-12 Issue:20 Volume:126 Page:2320-2328
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Carbonare Luca Dalle¹^ORCID,Matte’ Alessandro¹,Valenti Maria Teresa¹^ORCID,Siciliano Angela¹,Mori Antonio¹,Schweiger Vittorio²,Zampieri Gino³,Perbellini Luigi⁴,De Franceschi Lucia¹

Affiliation:

1. Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy;

2. Department of Surgical Science, Anesthesiology, Intensive Care and Pain Therapy Center, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy;

3. Advanced Consulting Engineering AC&E, Verona, Italy; and

4. Department of Public Health and Community Medicine, University of Verona, Verona, Italy

Abstract

Key Points In SCD, recurrent vaso-occlusive crisis suppresses osteogenic lineage and activates osteoclasts. Zoledronic acid acting on both osteoclast and osteoblast compartments is a multimodal therapy to prevent SBD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/20/2320/1389727/2320.pdf

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