von Willebrand factor is dimerized by protein disulfide isomerase

Author:

Lippok Svenja1,Kolšek Katra2,Löf Achim1,Eggert Dennis34,Vanderlinden Willem15,Müller Jochen P.1,König Gesa6,Obser Tobias6,Röhrs Karoline6,Schneppenheim Sonja7,Budde Ulrich7,Baldauf Carsten8,Aponte-Santamaría Camilo2,Gräter Frauke2,Schneppenheim Reinhard6,Rädler Joachim O.1,Brehm Maria A.6

Affiliation:

1. Faculty of Physics and Center for NanoScience, Ludwig Maximilian University, Munich, Germany;

2. Molecular Biomechanics Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany;

3. Max Planck Institute for the Structure and Dynamics of Matter, Hamburg, Germany;

4. Microscopy and Image Analysis Technology Platform, Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany;

5. Department of Chemistry, Division of Molecular Imaging and Photonics, Katholieke Universiteit Leuven-University of Leuven, Leuven, Belgium;

6. Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

7. Medilys Laborgesellschaft mbH, Hemostaseology, Asklepios Klinik Altona, Hamburg, Germany; and

8. Fritz-Haber-Institut der Max-Planck-Gesellschaft, Berlin, Germany

Abstract

Key Points The protein disulfide isomerase is involved in VWF dimerization by initiating disulfide bond formation at cysteines 2771 and 2773. von Willebrand disease-associated mutations in the dimerization domain of von Willebrand factor disturb processing by the protein disulfide isomerase.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3