Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry-Reference-Cited by-同舟云学术

Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry

Published:2015-08-20 Issue:8 Volume:126 Page:935-938
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chiu Po-Lin¹,Bou-Assaf George M.²,Chhabra Ekta Seth²,Chambers Melissa G.¹,Peters Robert T.²,Kulman John D.²,Walz Thomas¹³

Affiliation:

1. Department of Cell Biology, Harvard Medical School, Boston, MA;

2. Biogen, Cambridge, MA; and

3. Howard Hughes Medical Institute, Harvard Medical School, Boston, MA

Abstract

Key PointsElectron microscopy and hydrogen-deuterium exchange establish the C1 domain as the major binding site for the VWF D′D3 domain on FVIII. Additional sites implicated in the FVIII-VWF interaction are located within the a3 acidic peptide and the A3 and C2 domains of FVIII.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/8/935/1391421/935.pdf

Reference20 articles.

1. Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand’s disease.;Weiss;J Clin Invest,1977

2. Kinetics of factor VIII-von Willebrand factor association.;Vlot;Blood,1996

3. A revised classification of von Willebrand disease.;Sadler;Thromb Haemost,1994

4. New variant of von Willebrand disease with defective binding to factor VIII.;Nishino;Blood,1989

5. The international society on thrombosis and haematosis von Willebrand disease database: an update.;Hampshire;Semin Thromb Hemost,2011

Cited by 55 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Von Willebrand factor and hematogenous cancer metastasis under flow;Frontiers in Cell and Developmental Biology;2024-08-30

2. Binding Promiscuity of Therapeutic Factor VIII;Thrombosis and Haemostasis;2024-07-01

3. Genotype-Dependent Response to Desmopressin in Hemophilia A and Proposal of a Predictive Response Score;Thrombosis and Haemostasis;2024-05-17

4. In-depth structure-function profiling of the complex formation between clotting factor VIII and heme;Thrombosis Research;2024-05

5. von Willebrand factor modulates immune complexes and the recall response against factor VIII in a murine hemophilia A model;Blood Advances;2023-11-03