Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells-Reference-Cited by-同舟云学术

Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells

Published:2015-10-15 Issue:16 Volume:126 Page:1902-1910
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Linley Adam¹,Krysov Sergey²,Ponzoni Maurilio³,Johnson Peter W.¹,Packham Graham¹,Stevenson Freda K.¹

Affiliation:

1. Cancer Research UK Centre, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, United Kingdom;

2. Barts Cancer Institute, Queen Mary, University of London, John Vane Science Centre, Charterhouse Square, London, United Kingdom; and

3. Vita-Salute San Raffaele University, Pathology and Lymphoid Malignancies Unit, San Raffaele Scientific Institute, Milan, Italy

Abstract

Key Points Unusual sugars on the tips of sIg of FL cells interact with a tissue lectin to activate tumor-specific signaling. Activating lectin does not allow endocytosis of sIg, leading to persistent, essential, and targetable antigen-independent stimulation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/16/1902/1389438/1902.pdf

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4. Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins.;Coelho;Proc Natl Acad Sci USA,2010

5. Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.;Radcliffe;J Biol Chem,2007

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