Mechanism of quinine-dependent monoclonal antibody binding to platelet glycoprotein IIb/IIIa-Reference-Cited by-同舟云学术

Mechanism of quinine-dependent monoclonal antibody binding to platelet glycoprotein IIb/IIIa

Published:2015-10-29 Issue:18 Volume:126 Page:2146-2152
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bougie Daniel W.¹,Peterson Julie¹,Rasmussen Mark¹,Aster Richard H.¹²

Affiliation:

1. Blood Research Institute, BloodCenter of Wisconsin, and

2. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI

Abstract

Key Points Drug-induced modulation of antibody specificity appears to explain the binding of drug-dependent mAbs to αIIb/β3 integrin. Drug-dependent platelet antibodies differ greatly from classic hapten-specific antibodies and may be induced by a quite different mechanism.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/18/2146/1389385/2146.pdf

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