Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation-Reference-Cited by-同舟云学术

Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation

Published:2017-03-02 Issue:9 Volume:129 Page:1197-1209
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Naik Meghna U.¹,Patel Pravin¹,Derstine Randall¹²,Turaga Ramya²,Chen Xi¹,Golla Kalyan¹,Neeves Keith B.³,Ichijo Hidenori⁴,Naik Ulhas P.¹²^ORCID

Affiliation:

1. Cardeza Center for Vascular Biology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA;

2. Department of Biological Sciences, University of Delaware, Newark, DE;

3. Department of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO; and

4. Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan

Abstract

Key Points ASK1 regulates TxA2 generation through p38 MAPK-dependent phosphorylation of cPLA2. Because of impaired platelet function, Ask1−/− mice are protected from arterial thrombosis and pulmonary thromboembolism.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/9/1197/1403006/blood729780.pdf

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