Replication of associations between genetic polymorphisms and chronic graft-versus-host disease

Author:

Martin Paul J.12ORCID,Fan Wenhong3,Storer Barry E.14,Levine David M.4,Zhao Lue Ping3,Warren Edus H.12,Flowers Mary E. D.12,Lee Stephanie J.12,Carpenter Paul A.12,Boeckh Michael25,Hingorani Sangeeta6,Yan Li7,Hu Qiang7,Preus Leah89,Liu Song7,Spellman Stephen10,Zhu Xiaochun11,Pasquini Marcelo11,McCarthy Philip12,Stram Daniel13,Sheng Xin13,Pooler Loreall13,Haiman Christopher A.13,Sucheston-Campbell Lara89,Hahn Theresa7,Hansen John A.12

Affiliation:

1. Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Department of Medicine, University of Washington, Seattle, WA;

3. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA;

4. Department of Biostatistics, University of Washington, Seattle, WA;

5. Division of Vaccines and Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA;

6. Department of Pediatrics, University of Washington, Seattle, WA;

7. Department of Biostatistics & Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY;

8. College of Pharmacy and

9. College of Veterinary Medicine, The Ohio State University, Columbus, OH;

10. Center for International Blood and Marrow Transplant Research (CIBMTR), National Marrow Donor Program/Be The Match, Minneapolis, MN;

11. CIBMTR, Medical College of Wisconsin, Milwaukee, WI;

12. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY; and

13. Department of Preventive Medicine, University of Southern California, Los Angeles, CA

Abstract

Key Points Most published SNP associations with chronic GVHD are likely to represent false-positive findings. HRs for any true-positive SNP associations are likely to be much smaller than reported previously.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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