BLT-humanized C57BL/6 Rag2−/−γc−/−CD47−/− mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection

Author:

Lavender Kerry J.1,Pang Wendy W.2,Messer Ronald J.1,Duley Amanda K.1,Race Brent1,Phillips Katie1,Scott Dana3,Peterson Karin E.1,Chan Charles K.2,Dittmer Ulf4,Dudek Timothy5,Allen Todd M.5,Weissman Irving L.2,Hasenkrug Kim J.1

Affiliation:

1. Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT;

2. Institute for Stem Cell Biology and Regenerative Medicine, and the Ludwig Center for Cancer Cell Research, Stanford University School of Medicine, Stanford, CA;

3. Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT;

4. Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; and

5. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA

Abstract

Key Points Tolerance induced in the absence of CD47 signaling. C57BL/6 Rag2−/−γc−/−CD47−/− mice humanized without GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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