Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

Author:

Liu Zhi-Jian1,Hoffmeister Karin M.2,Hu Zhongbo3,Mager Donald E.4,Ait-Oudhia Sihem4,Debrincat Marlyse A.5,Pleines Irina5,Josefsson Emma C.5,Kile Benjamin T.5,Italiano Joseph26,Ramsey Haley1,Grozovsky Renata2,Veng-Pedersen Peter7,Chavda Chaitanya1,Sola-Visner Martha1

Affiliation:

1. Division of Newborn Medicine, Boston Children’s Hospital, Boston, MA;

2. Division of Translational Medicine, Brigham and Women’s Hospital, Boston, MA;

3. Division of Neonatology, University of Florida, Gainesville, FL;

4. Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY;

5. Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, and the Department of Medical Biology, University of Melbourne, Parkville, Australia;

6. Division of Hematology, Brigham and Women’s Hospital and the Vascular Biology Program, Boston Children’s Hospital, Boston, MA; and

7. College of Pharmacy, University of Iowa, Iowa City, IA

Abstract

Key Points Rapid growth and rising platelet counts result in a significant expansion of platelet mass during neonatal life. The rise in platelet counts is mediated by a prolongation in the neonatal platelet lifespan.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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