A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation-Reference-Cited by-同舟云学术

A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation

Published:2014-02-20 Issue:8 Volume:123 Page:1239-1249
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Klimenkova Olga¹,Ellerbeck Wienke¹,Klimiankou Maksim¹,Ünalan Murat¹,Kandabarau Siarhei¹,Gigina Anna¹,Hussein Kais²,Zeidler Cornelia¹,Welte Karl¹,Skokowa Julia¹

Affiliation:

1. Department of Molecular Hematopoiesis and

2. Department of Pathology, Hannover Medical School, Hannover, Germany

Abstract

Key Points The natural inhibitor of neutrophil elastase, SLPI, is severely reduced in severe congenital neutropenia patients. SLPI controls myeloid differentiation by regulation of NFκB, ERK1/2:LEF-1, and c-myc activation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/8/1239/1379178/1239.pdf

Reference50 articles.

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3. The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red Sea turtle proteinase inhibitor.;Seemüller;FEBS Lett,1986

4. The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils.;Jacobsen;J Leukoc Biol,2008

5. Secretory leukocyte proteinase inhibitor is a major leukocyte elastase inhibitor in human neutrophils.;Sallenave;J Leukoc Biol,1997

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