JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia-Reference-Cited by-同舟云学术

JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia

Published:2013-11-28 Issue:23 Volume:122 Page:3787-3797
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hobbs Catherine M.¹²,Manning Harriet¹²,Bennett Cavan¹²,Vasquez Louella³,Severin Sonia⁴,Brain Lauren⁴,Mazharian Alexandra⁴,Guerrero Jose A.²,Li Juan²,Soranzo Nicole²³,Green Anthony R.²,Watson Steve P.⁴,Ghevaert Cedric¹²

Affiliation:

1. National Health System Blood and Transplant, Cambridge, United Kingdom;

2. Department of Haematology, University of Cambridge, Cambridge, United Kingdom;

3. Wellcome Trust Sanger Institute, Cambridge, United Kingdom; and

4. University of Birmingham, Birmingham, United Kingdom

Abstract

Key Points JAK2V617F causes intrinsic changes in the process of platelet formation from megakaryocytes. JAK2V617F platelets are prothrombotic and demonstrate increased reactivity to different agonists.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/23/3787/1464465/3787.pdf

Reference59 articles.

1. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.;Levine;Cancer Cell,2005

2. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.;James;Nature,2005

3. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.;Baxter;Lancet,2005

4. A gain-of-function mutation of JAK2 in myeloproliferative disorders.;Kralovics;N Engl J Med,2005

5. Efficacy and safety of low-dose aspirin in polycythemia vera.;Landolfi;N Engl J Med,2004

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