An RCOR1 loss–associated gene expression signature identifies a prognostically significant DLBCL subgroup-Reference-Cited by-同舟云学术

An RCOR1 loss–associated gene expression signature identifies a prognostically significant DLBCL subgroup

Published:2015-02-05 Issue:6 Volume:125 Page:959-966
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chan Fong Chun¹²^ORCID,Telenius Adele¹,Healy Shannon¹,Ben-Neriah Susana¹,Mottok Anja¹,Lim Raymond¹^ORCID,Drake Marie¹,Hu Sandy¹,Ding Jiarui³^ORCID,Ha Gavin²³,Scott David W.¹,Kridel Robert¹,Bashashati Ali³,Rogic Sanja¹,Johnson Nathalie⁴,Morin Ryan D.⁵⁶^ORCID,Rimsza Lisa M.⁷,Sehn Laurie¹,Connors Joseph M.¹^ORCID,Marra Marco A.⁵⁸,Gascoyne Randy D.¹,Shah Sohrab P.³,Steidl Christian¹

Affiliation:

1. Center for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada;

2. Bioinformatics Graduate Program, University of British Columbia, Vancouver, BC, Canada;

3. Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada;

4. Department of Oncology, McGill University, Montreal, QC, Canada;

5. Genome Sciences Center, British Columbia Cancer Agency, Vancouver, BC, Canada;

6. Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada;

7. Department of Pathology, University of Arizona, Tucson, AZ; and

8. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

Abstract

Key Points Integration of genome-wide copy number and whole transcriptome data identifies key mutational events in the pathogenesis of DLBCL. Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in DLBCL patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/6/959/1387688/959.pdf

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