Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice-Reference-Cited by-同舟云学术

Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice

Published:2013-10-31 Issue:18 Volume:122 Page:3129-3137
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cheung Alice M. S.¹²,Nguyen Long V.¹,Carles Annaick³,Beer Philip¹,Miller Paul H.¹,Knapp David J. H. F.¹,Dhillon Kiran¹,Hirst Martin³⁴,Eaves Connie J.¹⁵

Affiliation:

1. Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada;

2. Department of Medicine, The University of Hong Kong, Hong Kong, China;

3. Centre for High-Throughput Biology, Department of Microbiology & Immunology, University of British Columbia, Vancouver, BC, Canada;

4. Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada; and

5. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

Abstract

Key Points The use of barcoding to track lineages in 196 human CD34+ CB clones in serially sampled primary and secondary transplanted NSG mice is described. Detection of early transient clones with later, more stable clones and definitive evidence of sustained self-renewal of multipotency is presented.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/18/3129/1370855/3129.pdf

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