Retinoic acid plus arsenic trioxide, the ultimate panacea for acute promyelocytic leukemia?

Author:

Lallemand-Breitenbach Valérie123,de Thé Hugues1234

Affiliation:

1. Université Paris Diderot, Sorbonne Paris Cité,

2. Institut National de la Sante et de la Recherche Medicale Unité Mixte de Recherche 944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d’Hématologie,

3. Centre National de la Recherche Scientifique Unité Mixte de Recherche 7212, and

4. Assistance Publique–Hôpitaux de Paris, Service de Biochimie, Hôpital St. Louis, Paris, France

Abstract

Abstract Rarely in the field of cancer treatment did we experience as many surprises as with acute promyelocytic leukemia (APL). Yet, the latest clinical trial reported by Lo-Coco et al in the New England Journal of Medicine is a practice-changing study, as it reports a very favorable outcome of virtually all enrolled low-intermediate risk patients with APL without any DNA-damaging chemotherapy. Although predicted from previous small pilot studies, these elegant and stringently controlled results open a new era in leukemia therapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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