Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis-Reference-Cited by-同舟云学术

Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis

Published:2015-07-23 Issue:4 Volume:126 Page:520-530
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sui Zhenhua¹,Nowak Roberta B.¹,Sanada Chad²,Halene Stephanie³,Krause Diane S.²,Fowler Velia M.¹

Affiliation:

1. Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA;

2. Department of Laboratory Medicine, Yale Stem Cell Center, and

3. Division of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT

Abstract

Key Points Tmod3-null embryos have macrothrombocytopenia due to impaired MK cytoplasmic morphogenesis with defective proplatelet formation. F-actin polymerization and organization are disrupted in Tmod3-null MKs and in their proplatelet buds.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/4/520/1391213/520.pdf

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