IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production-Reference-Cited by-同舟云学术

IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production

Published:2015-02-26 Issue:9 Volume:125 Page:1452-1459
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yáñez Alberto¹²^ORCID,Ng Madelena Y.¹²,Hassanzadeh-Kiabi Nargess¹²,Goodridge Helen S.¹²³

Affiliation:

1. Board of Governors Regenerative Medicine Institute and

2. Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA; and

3. David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA

Abstract

Key Points IRF8 does not instruct monocytic lineage specification in oligopotent granulocyte-monocyte progenitors. IRF8 regulates the survival and differentiation of lineage-committed progenitors to promote monocyte and suppress neutrophil production.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/9/1452/1388934/1452.pdf

Reference27 articles.

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