Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8-Reference-Cited by-同舟云学术

Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8

Published:2015-06-04 Issue:23 Volume:125 Page:3580-3587
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gounari Maria¹,Ntoufa Stavroula²,Apollonio Benedetta¹³,Papakonstantinou Nikos²,Ponzoni Maurilio¹³⁴,Chu Charles C.⁵,Rossi Davide⁶,Gaidano Gianluca⁶,Chiorazzi Nicholas⁵,Stamatopoulos Kostas²⁷,Ghia Paolo¹³

Affiliation:

1. Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele and Department of Onco-Hematology, Ospedale San Raffaele, Milan, Italy;

2. Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece;

3. Section of Internal Medicine, Università Vita-Salute San Raffaele, and

4. Pathology Unit, IRCCS Istituto Scientifico San Raffaele, Milan, Italy;

5. The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY;

6. Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy; and

7. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Abstract

Key Points mAbs from aggressive CLL subset #8 display extreme antigen polyreactivity, in clear contrast with the mAbs from other aggressive CLL subsets. Subset #8 CLL clones respond avidly to stimulation by multiple antigens and this may underlie their noted propensity to transform.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/23/3580/1387271/3580.pdf

Reference81 articles.

1. Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation.;Ghia;J Intern Med,2008

2. The microenvironment in mature B-cell malignancies: a target for new treatment strategies.;Burger;Blood,2009

3. Chronic lymphocytic leukemia.;Chiorazzi;N Engl J Med,2005

4. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia.;Chen;Blood,2002

5. Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia.;Lanham;Blood,2003

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