Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates

Author:

He Qiuping1,Zhang Chunxia1,Wang Lu1,Zhang Panpan1,Ma Dongyuan1,Lv Junhua1,Liu Feng1

Affiliation:

1. State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

Abstract

Key Points TLR4–MyD88–NF-κB is required for HSPC emergence in zebrafish and mouse embryos. Notch functions downstream of inflammatory signaling to regulate HSPC emergence.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference67 articles.

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