A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia

Author:

Petersdorf Stephen H.1,Kopecky Kenneth J.12,Slovak Marilyn3,Willman Cheryl4,Nevill Thomas5,Brandwein Joseph6,Larson Richard A.7,Erba Harry P.8,Stiff Patrick J.9,Stuart Robert K.10,Walter Roland B.1,Tallman Martin S.11,Stenke Leif12,Appelbaum Frederick R.1

Affiliation:

1. Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Southwest Oncology Group Statistical Center, Seattle, WA;

3. City of Hope Medical Center, Duarte, CA;

4. University of New Mexico, Albuquerque, NM;

5. Vancouver General Hospital, Vancouver, BC, Canada;

6. University of Toronto, Toronto, Ontario, Canada;

7. University of Chicago, Chicago, IL;

8. University of Michigan, Ann Arbor, MI;

9. Loyola University Medical Center, Maywood, IL;

10. Medical University of South Carolina, Charleston, SC;

11. Memorial Sloan-Kettering Cancer Center, New York, NY; and

12. Karolinska University Hospital, Stockholm, Sweden

Abstract

Key Points The addition of gemtuzumab ozogamicin to induction or maintenance therapy failed to improve the complete response rate or overall survival in patients with acute myeloid leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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