Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia

Published:2013-08-29 Issue:9 Volume:122 Page:1587-1598
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Koss Brian¹,Morrison Jeffrey²,Perciavalle Rhonda M.¹³,Singh Harpreet²³,Rehg Jerold E.⁴,Williams Richard T.²,Opferman Joseph T.¹

Affiliation:

1. Department of Biochemistry and

2. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN;

3. Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, TN; and

4. Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN

Abstract

Key Points Using a mouse genetic mouse model of Ph+ B-lineage ALL, endogenous antiapoptotic MCL-1 is required for leukemia survival. In BCR-ABL+ B-lineage ALL human and mouse cells, combining TKIs with small-molecule inhibitors of BCL-2 can potentiate sensitivity to cell death.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/9/1587/1373459/1587.pdf

Reference56 articles.

1. New therapeutic strategies for the treatment of acute lymphoblastic leukaemia.;Pui;Nat Rev Drug Discov,2007

2. Patients’ age and BCR-ABL frequency in adult B-precursor ALL: a retrospective analysis from the GMALL study group.;Burmeister;Blood,2008

3. Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.;Rowley;Nature,1973

4. Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL.;Clark;Science,1987

5. Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine.;Witte;Nature,1980

Cited by 84 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chemotherapy-free treatment of VAF induces early and deep molecular response in patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia: a prospective, single-center, single-arm, phase 2 trial;2024-07-12

2. Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1;Molecular Cell;2024-04

3. Application of molecular dynamics-based pharmacophore and machine learning approaches to identify novel Mcl1 inhibitors through drug repurposing and mechanics research;Physical Chemistry Chemical Physics;2024

4. Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction;Cell Reports;2023-10

5. Histone demethylase PHF8 facilitates the development of chronic myeloid leukaemia by directly targeting BCR::ABL1;British Journal of Haematology;2023-07-19