Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages

Author:

Gibbings Sophie L.1,Goyal Rajni1,Desch A. Nicole2,Leach Sonia M.3,Prabagar Miglena1,Atif Shaikh M.1,Bratton Donna L.1,Janssen William4,Jakubzick Claudia V.12

Affiliation:

1. Department of Pediatrics,

2. Department of Immunology and Microbiology,

3. Integrated Center for Genes, Environment, and Health, and

4. Department of Medicine, National Jewish Health and University of Colorado Denver Anschutz Campus, Denver, CO

Abstract

Key Points Of the 30 000 genes, there are ∼0.1% genes whose expression is linked to the origin of the cell rather than the environment. Marco was most conserved by embryonic origin and not altered by the environment, whereas C1qb and Plbd1 were most conserved by adult origin.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference50 articles.

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3. The role of alveolar macrophages in regulation of lung inflammation.;Thepen;Ann N Y Acad Sci,1994

4. Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections.;Guilliams;Mucosal Immunol,2013

5. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages.;Gautier;Nat Immunol,2012

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