Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma-Reference-Cited by-同舟云学术

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma

Published:2015-09-24 Issue:13 Volume:126 Page:1555-1564
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bhatt Shruti¹²,Matthews Julie¹²,Parvin Salma²³,Sarosiek Kristopher A.¹²,Zhao Dekuang²³,Jiang Xiaoyu²,Isik Elif⁴,Letai Anthony⁴⁵,Lossos Izidore S.¹²

Affiliation:

1. Department of Molecular and Cellular Pharmacology and

2. Department of Medicine, Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, Miami, FL;

3. Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, FL;

4. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; and

5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA

Abstract

Key Points IL-21 activates IL-21R–dependent singling to mediate direct cytotoxicity of MCL cells. Indirect effects of IL-21 on immune effector cells also contribute to antitumor effects against MCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/13/1555/1388839/1555.pdf

Reference50 articles.

1. Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics.;Jares;Nat Rev Cancer,2007

2. Mantle cell lymphoma: a clinicopathologic study of 80 cases.;Argatoff;Blood,1997

3. Mantle cell lymphoma: a retrospective study of 121 cases.;Samaha;Leukemia,1998

4. Mantle cell lymphoma: clinical features, treatment and prognosis of 94 patients.;Oinonen;Eur J Cancer,1998

5. Current treatment approaches for mantle-cell lymphoma.;Witzig;J Clin Oncol,2005

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