RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1-Reference-Cited by-同舟云学术

RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1

Published:2015-08-13 Issue:7 Volume:126 Page:880-890
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ear Jason¹,Huang Haigen¹,Wilson Tianna¹,Tehrani Zahra¹,Lindgren Anne¹,Sung Victoria²,Laadem Abderrahmane³,Daniel Thomas O.³,Chopra Rajesh³,Lin Shuo¹

Affiliation:

1. Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA;

2. Celgene Corporation, San Francisco, CA; and

3. Celgene Corporation, Summit, NJ

Abstract

Key Points Ribosome deficiency in zebrafish leads to defects in erythroid maturation and is reversed by RAP-011 treatment. Identification of lefty1 as a key mediator of erythropoiesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/7/880/1391040/880.pdf

Reference54 articles.

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2. Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry.;Vlachos;Blood,2012

3. Ribosomal protein S19 expression during erythroid differentiation.;Da Costa;Blood,2003

4. The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia.;Draptchinskaia;Nat Genet,1999

5. Ten novel Diamond-Blackfan anemia mutations and three polymorphisms within the rps19 gene.;Proust;Hematol J,2003

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