Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency-Reference-Cited by-同舟云学术

Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency

Published:2015-04-23 Issue:17 Volume:125 Page:2665-2668
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Jiang Wenxia¹²,Lee Brian J.¹²,Li Chen¹²,Dubois Richard L.¹²,Gostissa Monica³,Alt Frederick W.³,Zha Shan¹²⁴

Affiliation:

1. Department of Pathology and Cell Biology, Institute for Cancer Genetics, and

2. Herbert Irving Comprehensive Cancer Research Center, Columbia University Medical Center, New York, NY;

3. Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, and Department of Genetics, Harvard Medical School, Boston, MA; and

4. Division of Hematology, Oncology, and Stem Cell Transplantation, Department of Pediatrics, College for Physicians and Surgeons, Columbia University Medical Center, New York, NY

Abstract

Key Points ATM-deficient T-cell lymphocytopenia is in part caused by defects in TCRδ rearrangements. Aberrant TCRδ arrangement is required for the recurrent t(12;14) translocations, but not chromosome 14 amplification, in ATM-deficient thymic lymphomas.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/17/2665/1385309/2665.pdf

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4. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.;Borghesani;Proc Natl Acad Sci USA,2000

5. Atm-deficient mice: a paradigm of ataxia telangiectasia.;Barlow;Cell,1996

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