High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia

Author:

Lucena-Araujo Antonio R.1,Kim Haesook T.2,Thomé Carolina1,Jacomo Rafael H.1,Melo Raul A.3,Bittencourt Rosane4,Pasquini Ricardo5,Pagnano Katia6,Glória Ana Beatriz F.7,Chauffaille Maria de Lourdes8,Athayde Melina7,Chiattone Carlos S.9,Mito Ingrid4,Bendlin Rodrigo5,Souza Carmino6,Bortolheiro Cristina9,Coelho-Silva Juan L.10,Schrier Stanley L.11,Tallman Martin S.12,Grimwade David13,Ganser Arnold14,Berliner Nancy15,Ribeiro Raul C.16,Lo-Coco Francesco1718,Löwenberg Bob19,Sanz Miguel A.20,Rego Eduardo M.1

Affiliation:

1. Department of Internal Medicine, Medical School of Ribeirao Preto and Center for Cell Based Therapy, University of São Paulo, Ribeirao Preto, Brazil;

2. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA;

3. Department of Internal Medicine, University of Pernambuco and Fundação HEMOPE, Recife, Brazil;

4. Hematology Division, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;

5. Hematology Division, Federal University of Paraná, Curitiba, Brazil;

6. Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil;

7. Hematology Division, Federal University of Minas Gerais, Belo Horizonte, Brazil;

8. Hematology and Transfusion Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil;

9. Hematology Division, Santa Casa Medical School, Sao Paulo, Brazil;

10. Department of Genetics, Federal University of Pernambuco, Recife, Brazil;

11. Department of Medicine, Stanford University, Stanford, CA;

12. Leukemia Service, Memorial Sloan Kettering Cancer Center/Weill Cornell Medical College, New York, NY;

13. Department of Medical and Molecular Genetics, King’s College London School of Medicine, London, United Kingdom;

14. Department of Hematology, Hannover Medical School, Hannover, Germany;

15. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;

16. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN;

17. Department of Biopathology, University Tor Vergata, Rome, Italy;

18. Santa Lucia Foundation, Rome, Italy;

19. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands; and

20. Department of Hematology, Valencia University Medical School, Valencia, Spain

Abstract

Key Points High ΔNp73/TAp73 expression ratio is associated with lower overall survival and higher cumulative incidence of relapse in APL. ΔNp73/TAp73 expression ratio is an independent prognostic marker in APL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference28 articles.

1. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.;Grob;Cell Death Differ,2001

2. p73 is a simian [correction of human] p53-related protein that can induce apoptosis.;Jost;Nature,1997

3. Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73.;Ishimoto;Cancer Res,2002

4. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death.;Pozniak;Science,2000

5. DNp73 a matter of cancer: mechanisms and clinical implications.;Buhlmann;Biochim Biophys Acta,2008

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3