Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds-Reference-Cited by-同舟云学术

Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds

Published:2015-07-02 Issue:1 Volume:126 Page:50-60
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lagrue Kathryn¹²,Carisey Alex¹,Morgan David J.¹,Chopra Rajesh³,Davis Daniel M.¹

Affiliation:

1. Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom;

2. Department of Life Sciences, Imperial College London, London, United Kingdom; and

3. Department of Translational Development, Celgene Corporation, Summit, NJ

Abstract

Key Points Lenalidomide augments nanoscale rearrangements in cortical actin at the human NK-cell immune synapse. Lenalidomide lowers the threshold for NK-cell activation, allowing activation by low levels of ligands on tumor cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/1/50/1345516/50.pdf

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