Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice-Reference-Cited by-同舟云学术

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice

Published:2015-10-08 Issue:15 Volume:126 Page:1844-1855
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Arumugam Paritha I.¹,Mullins Eric S.²^ORCID,Shanmukhappa Shiva Kumar³,Monia Brett P.⁴,Loberg Anastacia¹,Shaw Maureen A.²,Rizvi Tilat¹,Wansapura Janaka⁵,Degen Jay L.¹,Malik Punam¹²

Affiliation:

1. Division of Experimental Hematology and Cancer Biology,

2. Division of Hematology, Cancer and Blood Diseases Institute, and

3. Department of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH;

4. Department of Antisense Drug Discovery, Isis Pharmaceuticals, Carlsbad, CA; and

5. Imaging Research Center, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Abstract

Key PointsReduced prothrombin improves survival and ameliorates inflammation and end-organ damage without spontaneous bleeding in sickle cell mice. An individual procoagulant, prothrombin, represents a novel therapeutic target that can improve sickle cell disease outcome.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/15/1844/1389609/1844.pdf

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5. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.;Reiter;Nat Med,2002

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