Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice-Reference-Cited by-同舟云学术

Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice

Published:2015-09-17 Issue:12 Volume:126 Page:1503-1514
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wikstrom Matthew E.¹²,Fleming Peter¹²,Kuns Rachel D.³,Schuster Iona S.¹²,Voigt Valentina¹²,Miller Gregory⁴,Clouston Andrew D.⁴,Tey Siok-Keen³,Andoniou Christopher E.¹²,Hill Geoffrey R.¹³,Degli-Esposti Mariapia A.¹²

Affiliation:

1. Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, WA, Australia;

2. Centre for Experimental Immunology, Lions Eye Institute, Nedlands, WA, Australia;

3. Bone Marrow Transplantation Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; and

4. Envoi Pathology, Brisbane, QLD, Australia

Abstract

Key Points GVHD elicits profound defects in DCs that prevent the priming of virus-specific T cells. Transfer of polyclonal T cells from immune donors at transplant provides effective antiviral immunity despite the presence of active GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/12/1503/1388199/1503.pdf

Reference44 articles.

1. The biology of graft-versus-host disease: experimental systems instructing clinical practice.;Markey;Blood,2014

2. The impact of cytomegalovirus serostatus of donor and recipient before hematopoietic stem cell transplantation in the era of antiviral prophylaxis and preemptive therapy.;Boeckh;Blood,2004

3. Increased transplant-related morbidity and mortality in CMV-seropositive patients despite highly effective prevention of CMV disease after allogeneic T-cell-depleted stem cell transplantation.;Broers;Blood,2000

4. Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis.;Ljungman;Blood,2003

5. How we treat cytomegalovirus in hematopoietic cell transplant recipients.;Boeckh;Blood,2009

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation;Journal of Clinical Investigation;2024-04-01

2. CMV infection combined with acute GVHD associated with poor CD8+ T-cell immune reconstitution and poor prognosis post-HLA-matched allo-HSCT;Clinical and Experimental Immunology;2022-05-12

3. Cytomegalovirus gastroenteritis in patients with acute graft-versus-host disease;Blood Advances;2022-01-19

4. CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant;Blood;2021-12-30

5. Optimizing Allogeneic Grafts in Hematopoietic Stem Cell Transplantation;Stem Cells Translational Medicine;2021-11-01