Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD-Reference-Cited by-同舟云学术

Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD

Published:2015-07-23 Issue:4 Volume:126 Page:437-444
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chopra Martin¹²,Brandl Andreas¹²,Siegmund Daniela³,Mottok Anja⁴,Schäfer Viktoria³,Biehl Marlene¹²,Kraus Sabrina¹²⁵,Bäuerlein Carina A.¹²,Ritz Miriam¹²,Mattenheimer Katharina¹²,Schwinn Stefanie¹²,Seher Axel⁶,Grabinger Thomas⁷,Einsele Hermann¹,Rosenwald Andreas⁴,Brunner Thomas⁷,Beilhack Andreas¹²⁵,Wajant Harald³

Affiliation:

1. Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany;

2. Center for Interdisciplinary Clinical Research, University of Würzburg, Würzburg, Germany;

3. Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany;

4. Institute of Pathology, University of Würzburg and Comprehensive Cancer Center Mainfranken, Würzburg, Germany;

5. Else-Kröner-Forschungskolleg Würzburg, Würzburg, Germany;

6. Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Würzburg, Germany; and

7. Department of Biology, University of Konstanz, Konstanz, Germany

Abstract

Key Points Fn14 activation is involved in intestinal apoptosis after allo-HCT and contributes to gastrointestinal GVHD. Fn14 blockade with an ADCC-defective human immunoglobulin G1 antibody reduces GVHD severity without modulating GVL responses.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/4/437/1390653/437.pdf

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3. The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration.;Meighan-Mantha;J Biol Chem,1999

4. TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity.;Donohue;Arterioscler Thromb Vasc Biol,2003

5. Expression and function of fibroblast growth factor-inducible 14 in human corneal myofibroblasts.;Ebihara;Exp Eye Res,2009

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