The polyphosphate–factor XII pathway drives coagulation in prostate cancer-associated thrombosis

Author:

Nickel Katrin F.123,Ronquist Göran4,Langer Florian5,Labberton Linda23,Fuchs Tobias A.1,Bokemeyer Carsten5,Sauter Guido6,Graefen Markus7,Mackman Nigel8,Stavrou Evi X.910,Ronquist Gunnar4,Renné Thomas123

Affiliation:

1. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

2. Division of Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;

3. Center of Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden;

4. Clinical Chemistry, Department of Medical Sciences, Clinical Chemistry, University Hospital of Uppsala, Uppsala, Sweden;

5. Clinical Department of Hematology and Oncology, Center for Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

6. Institute for Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

7. Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

8. Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC;

9. Divisions of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH; and

10. Department of Medicine, Louis Stokes Veterans Administration Hospital, Cleveland, OH

Abstract

Key Points Polyphosphate-activated coagulation factor XII drives prostate cancer-associated venous thrombosis. Targeting the polyphosphate/factor XII pathway reduces procoagulant activity in prostate cancer patient plasma and may permit safe anticoagulation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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