Prognostic miRNA classifier in early-stage mycosis fungoides: development and validation in a Danish nationwide study

Author:

Lindahl Lise M.1ORCID,Besenbacher Søren2,Rittig Anne H.1,Celis Pamela2,Willerslev-Olsen Andreas3,Gjerdrum Lise M. R.4,Krejsgaard Thorbjørn3,Johansen Claus1,Litman Thomas3,Woetmann Anders3,Odum Niels3,Iversen Lars1ORCID

Affiliation:

1. Department of Dermatology and

2. Department of Molecular Medicine, Aarhus University, Aarhus, Denmark;

3. Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark; and

4. Department of Pathology, Zealand University Hospital, Roskilde, Denmark

Abstract

Key Points A validated 3-miRNA classifier can effectively predict progression from early- to advanced-stage MF and survival at time of diagnosis. This classifier outperforms existing clinical prognostic factors and paves the way for implementation of personalized treatment in MF.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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