BAFF and CD4+ T cells are major survival factors for long-lived splenic plasma cells in a B-cell–depletion context-Reference-Cited by-同舟云学术

BAFF and CD4+ T cells are major survival factors for long-lived splenic plasma cells in a B-cell–depletion context

Published:2018-04-05 Issue:14 Volume:131 Page:1545-1555
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Thai Lan-Huong¹²,Le Gallou Simon¹,Robbins Ailsa¹,Crickx Etienne¹,Fadeev Tatiana¹,Zhou Zhicheng¹,Cagnard Nicolas³,Mégret Jérôme⁴,Bole Christine⁵,Weill Jean-Claude¹,Reynaud Claude-Agnès¹,Mahévas Matthieu¹²

Affiliation:

1. Institut Necker-Enfants Malades-INSERM U1151/Centre National de la Recherche (CNRS) UMR8633, Université Paris Descartes, Faculté de Médecine, Paris, France;

2. Service de Médecine Interne, Centre de Référence des Cytopénies Auto-immunes de l'Adulte, Hôpital Henri Mondor, Assistance Publique Hôpitaux de Paris, Université Paris Est Créteil, Créteil, France;

3. Plateforme de Bioinformatique, Université Paris Descartes-Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS3633, Paris, France;

4. Plateforme de Cytométrie en Flux, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS3633, Paris, France; and

5. Plateforme Génomique, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163 and INSERM US24/CNRS UMS3633, Paris, France

Abstract

Key Points Modification of the splenic microenvironment induced by B-cell depletion creates a dependence of PCs on BAFF and CD4+ T cells. Combining anti-CD20 and anti-BAFF reduces the number of splenic PCs, opening therapeutic perspectives for antibody-mediated cytopenia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/14/1545/1405914/blood789578.pdf

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