Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypia-Reference-Cited by-同舟云学术

Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypia

Published:2016-09-08 Issue:10 Volume:128 Page:1418-1423
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kapralova Katarina¹²³,Horvathova Monika¹,Pecquet Christian²³,Fialova Kucerova Jana¹^ORCID,Pospisilova Dagmar⁴,Leroy Emilie²³,Kralova Barbora¹,Milosevic Feenstra Jelena D.⁵^ORCID,Schischlik Fiorella⁵,Kralovics Robert⁵^ORCID,Constantinescu Stefan N.²³,Divoky Vladimir¹

Affiliation:

1. Department of Biology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic;

2. Signal Transduction and Molecular Hematology Unit, Ludwig Institute for Cancer Research, Brussels, Belgium;

3. de Duve Institute, Université catholique de Louvain, Brussels, Belgium;

4. Department of Pediatrics, University Hospital and Faculty of Medicine and Dentistry, Olomouc, Czech Republic; and

5. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

Abstract

Key Points Cells expressing JAK2 E846D or R1063H exhibit pathologic STAT5 activation in the specific context of EPOR. Cooperation of germ line JAK2 mutations E846D and R1063H defines a JAK2-signaling threshold for induction of erythrocytosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/10/1418/1395128/1418.pdf

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