Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor-Reference-Cited by-同舟云学术

Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor

Published:2016-09-29 Issue:13 Volume:128 Page:1766-1776
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wijeyewickrema Lakshmi C.¹,Lameignere Emilie²,Hor Lilian¹,Duncan Renee C.¹,Shiba Toshikazu³,Travers Richard J.⁴,Kapopara Piyushkumar R.²,Lei Victor²,Smith Stephanie A.⁴,Kim Hugh²⁵,Morrissey James H.⁴,Pike Robert N.¹,Conway Edward M.²

Affiliation:

1. Department of Biochemistry and Genetics and ARC Centre for Advanced Molecular Imaging, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia;

2. Centre for Blood Research, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;

3. Regenetiss Inc., Tokyo, Japan;

4. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL; and

5. Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada

Abstract

Key PointsPolyP, like heparin, is a physiologic cofactor for the C1-INH:C1s interaction, and thus a key negative regulator of complement. Colocalization of polyP with C1-INH in activated platelets suggests that its cofactor function is physiologically relevant.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/13/1766/1395834/1766.pdf

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