Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency-Reference-Cited by-同舟云学术

Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency

Published:2016-06-23 Issue:25 Volume:127 Page:3253-3259
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Theocharides Alexandre P. A.¹^ORCID,Lundberg Pontus²,Lakkaraju Asvin K. K.³,Lysenko Veronika¹,Myburgh Renier¹,Aguzzi Adriano³,Skoda Radek C.²,Manz Markus G.¹

Affiliation:

1. Division of Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland;

2. Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, Basel, Switzerland; and

3. Institute of Neuropathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland

Abstract

Key Points Acquired MPO deficiency in patients with MPN is uniquely associated with homozygous CALR mutations. In line with a posttranscriptional defect, MPO deficiency results from reduced MPO protein levels, but not from decreased MPO mRNA.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/25/3253/1353446/3253.pdf

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