IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells-Reference-Cited by-同舟云学术

IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells

Published:2016-09-15 Issue:11 Volume:128 Page:1475-1489
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mao Yumeng¹,van Hoef Vincent²,Zhang Xiaonan¹³,Wennerberg Erik¹⁴,Lorent Julie²,Witt Kristina¹,Masvidal Laia²,Liang Shuo²^ORCID,Murray Shannon⁵,Larsson Ola²,Kiessling Rolf¹,Lundqvist Andreas¹⁵^ORCID

Affiliation:

1. Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden;

2. Department of Oncology-Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden;

3. Department of Medical and Health Sciences, Linköping University, Linköping, Sweden;

4. Department of Radiation Oncology, Weill Cornell Medicine, New York, NY; and

5. Cell Therapy Institute, Nova Southeastern University, Fort Lauderdale, FL

Abstract

Key Points Cytokine-activated NK cells display distinct gene expression programs in response to cytokine withdrawal. IL-15 sustains antitumor functions of NK cells through mTOR-governed metabolic processes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/11/1475/1395288/1475.pdf

Reference57 articles.

1. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer.;Miller;Blood,2005

2. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants.;Ruggeri;Science,2002

3. Allogeneic natural killer cells for refractory lymphoma.;Bachanova;Cancer Immunol Immunother,2010

4. Interleukin 15: biology and relevance to human disease.;Fehniger;Blood,2001

5. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design.;Waldmann;Nat Rev Immunol,2006

Cited by 137 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Striking a balance: the Goldilocks effect of CD8α expression on NK cells;Journal of Clinical Investigation;2024-08-01

2. A Critical Role of Culture Medium Selection in Maximizing the Purity and Expansion of Natural Killer Cells;Cells;2024-07-05

3. Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation;Journal of Clinical Investigation;2024-05-28

4. IL-15 as a key regulator in NK cell-mediated immunotherapy for cancer: From bench to bedside;International Immunopharmacology;2024-05

5. Therapeutic potential of natural killer cells in neuroimmunological diseases;Biomedicine & Pharmacotherapy;2024-04