Evolution of acute myelogenous leukemia stem cell properties after treatment and progression-Reference-Cited by-同舟云学术

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression

Published:2016-09-29 Issue:13 Volume:128 Page:1671-1678
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ho Tzu-Chieh¹^ORCID,LaMere Mark²,Stevens Brett M.³,Ashton John M.⁴^ORCID,Myers Jason R.⁴^ORCID,O’Dwyer Kristen M.²,Liesveld Jane L.²^ORCID,Mendler Jason H.²,Guzman Monica⁵,Morrissette Jennifer D.⁶,Zhao Jianhua⁶,Wang Eunice S.⁷,Wetzler Meir⁷,Jordan Craig T.³^ORCID,Becker Michael W.²^ORCID

Affiliation:

1. Department of Biomedical Engineering, Columbia University, New York, NY;

2. Department of Medicine, J. P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY;

3. Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO;

4. Genomics Research Center, J. P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY;

5. Department of Pharmacology in Medicine, Weill Medical College of Cornell University, New York, NY;

6. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and

7. Leukemia Service, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY

Abstract

Key Points Using AML as a model, we investigated the effect of treatment and disease evolution on functionally defined cancer stem cell populations. We demonstrate large-scale changes in LSC frequency and phenotype after relapse, best described using high-dimensional space analyses.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/13/1671/1395319/1671.pdf

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