PD-L1 expression on neoplastic or stromal cells is respectively a poor or good prognostic factor for adult T-cell leukemia/lymphoma

Author:

Miyoshi Hiroaki1,Kiyasu Junichi2,Kato Takeharu13,Yoshida Noriaki1,Shimono Joji1,Yokoyama Shintaro4,Taniguchi Hiroaki5,Sasaki Yuya1,Kurita Daisuke1,Kawamoto Keisuke1,Kato Koji6,Imaizumi Yoshitaka3,Seto Masao1,Ohshima Koichi1

Affiliation:

1. Department of Pathology, Kurume University School of Medicine, Kurume, Japan;

2. Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

3. Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan;

4. Department of Surgery, Kurume University School of Medicine, Kurume, Japan;

5. Department of Hematology, Sasebo City General Hospital, Sasebo, Japan; and

6. Department of Medicine and Biosystemic Science, Kyushu University Faculty of Medicine, Fukuoka, Japan

Abstract

Key Points PD-L1 expression in neoplastic cells or stromal cells is associated with poor or good prognosis in ATLL, respectively. Distinction of expression pattern of PD-L1 might be important on the point of prognostic and therapeutic markers in ATLL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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