Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation-Reference-Cited by-同舟云学术

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation

Published:2016-10-20 Issue:16 Volume:128 Page:2022-2032
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Aguilar Alicia¹²³⁴,Pertuy Fabien¹²³⁴,Eckly Anita¹²³⁴,Strassel Catherine¹²³⁴,Collin Dominique⁵,Gachet Christian¹²³⁴,Lanza François¹²³⁴,Léon Catherine¹²³⁴^ORCID

Affiliation:

1. INSERM, Unité Mixte de Recherche en Santé 949, Strasbourg, France;

2. Etablissement Français du Sang, Strasbourg, France;

3. Faculté de Médecine, Université de Strasbourg, Strasbourg, France;

4. Fédération de Médecine Translationnelle, Strasbourg, France; and

5. Institut Charles Sadron, UPR 22, Strasbourg, France

Abstract

Key Points Mimicking 3D BM stiffness improves MK maturation with in situ–like morphology and higher ploidy and proplatelet formation. The myosin IIA and MKL1 pathways contribute to 3D hydrogel medium-mediated increased proplatelet formation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/16/2022/1396509/2022.pdf

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