The genetics of nodal marginal zone lymphoma

Author:

Spina Valeria1,Khiabanian Hossein2,Messina Monica3,Monti Sara1,Cascione Luciano4,Bruscaggin Alessio1,Spaccarotella Elisa1,Holmes Antony B.5,Arcaini Luca6,Lucioni Marco7,Tabbò Fabrizio8,Zairis Sakellarios2,Diop Fary1,Cerri Michaela1,Chiaretti Sabina3,Marasca Roberto9,Ponzoni Maurilio10,Deaglio Silvia11,Ramponi Antonio12,Tiacci Enrico13,Pasqualucci Laura5,Paulli Marco7,Falini Brunangelo13,Inghirami Giorgio81415,Bertoni Francesco4,Foà Robin3,Rabadan Raul2,Gaidano Gianluca1,Rossi Davide14

Affiliation:

1. Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy;

2. Department of Biomedical Informatics and Systems Biology, Columbia University, New York, NY;

3. Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy;

4. Institute of Oncology Research and Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;

5. Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY;

6. Department of Hematology-Oncology, Fondazione IRCCS Policlinico San Matteo and Department of Molecular Medicine, University of Pavia, Pavia, Italy;

7. Division of Pathology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy;

8. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY;

9. Division of Hematology, Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy;

10. Ateneo Vita-Salute and Unit of Lymphoid Malignancies, San Raffaele H. Scientific Institute, Milan, Italy;

11. Department of Medical Sciences, University of Torino and Immunogenetics Unit, Human Genetics Foundation, Torino, Italy;

12. Division of Pathology, Department of Health Sciences, Amedeo Avogadro University of Eastern Piedmont and Maggiore Hospital, Novara, Italy;

13. Institute of Hematology, Ospedale S. Maria della Misericordia, University of Perugia, Perugia, Italy;

14. Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, Torino, Italy; and

15. Department of Pathology, NYU Cancer Center, New York University School of Medicine, New York, NY

Abstract

Key Points PTPRD lesions are among the most recurrent alterations in NMZL and appear to be enriched in this lymphoma type across mature B-cell tumors. NMZL and SMZL genetics overlap with the exceptions of PTPRD lesions, supporting their distinction as independent entities.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference69 articles.

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