Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas

Author:

Vallois David1ORCID,Dobay Maria Pamela D.2,Morin Ryan D.34,Lemonnier François5,Missiaglia Edoardo1,Juilland Mélanie6,Iwaszkiewicz Justyna2,Fataccioli Virginie5,Bisig Bettina1,Roberti Annalisa1,Grewal Jasleen3,Bruneau Julie7,Fabiani Bettina8,Martin Antoine9,Bonnet Christophe10,Michielin Olivier211,Jais Jean-Philippe12,Figeac Martin13,Bernard Olivier A.14,Delorenzi Mauro21115,Haioun Corinne16,Tournilhac Olivier17,Thome Margot6,Gascoyne Randy D.18,Gaulard Philippe5,de Leval Laurence1

Affiliation:

1. Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;

2. SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland;

3. Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada;

4. Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada;

5. INSERM U955, Université Paris-Est, Département de Pathologie, Hôpital Henri-Mondor, Créteil, France;

6. Department of Biochemistry, University of Lausanne, Lausanne, Switzerland;

7. Service d’Anatomie et cytologie pathologiques, Hôpital Necker, Paris, France;

8. Service d’Anatomie et cytologie pathologiques, Hôpital Saint-Antoine, Paris, France;

9. Service d’Anatomie pathologique, Hôpital Avicenne, Bobigny, France;

10. Hématologie clinique, CHU Liège, Liège, Belgium;

11. Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;

12. Service de Biostatistiques, GH Necker-Enfants Malades, Paris, France;

13. Plate-forme de Génomique Fonctionnelle et Structurale, Institut Pour la Recherche sur le Cancer de Lille, Lille, France;

14. INSERM U1170, Institut Gustave Roussy, Villejuif, France;

15. Ludwig Center for Cancer Research, University of Lausanne, Epalinges, Switzerland;

16. Hémopathies lymphoides, CHU Henri Mondor, Creteil, France;

17. Hématologie Clinique, CHU Estaing, Clermont-Ferrand, France; and

18. Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, BC, Canada

Abstract

Key Points A high frequency of diverse activating mutations in costimulatory/TCR-related signaling genes occurs in AITL and other TFH-derived PTCL. Deregulated TCR activation may play a role in the pathogenesis of TFH-derived PTCL, paving the way for developing novel targeted therapies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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