GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow-Reference-Cited by-同舟云学术

GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow

Published:2015-05-21 Issue:21 Volume:125 Page:3306-3315
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ohmori Shin’ya¹,Moriguchi Takashi²,Noguchi Yuki¹,Ikeda Muneharu¹,Kobayashi Kota¹,Tomaru Nazuki¹,Ishijima Yasushi¹,Ohneda Osamu³,Yamamoto Masayuki²,Ohneda Kinuko¹

Affiliation:

1. Department of Pharmacy, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Japan;

2. Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan; and

3. Graduate School of Comprehensive Human Sciences, Laboratory of Regenerative Medicine and Stem Cell Biology, University of Tsukuba, Tsukuba, Japan

Abstract

Key Points Mouse BM-derived mast cells can dedifferentiate into immature myeloid-like cells after the deletion of the GATA2 DNA binding domain. Increased expression of C/EBPα is critical for the dedifferentiation of GATA2-deficient mast cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/21/3306/1386153/3306.pdf

Reference42 articles.

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2. Essential role of GATA transcriptional factors in the activation of mast cells.;Masuda;J Immunol,2007

3. Regulation of GATA factor expression is distinct between erythroid and mast cell lineages.;Ohmori;Mol Cell Biol,2012

4. Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice.;Ohneda;Mol Cell Biol,2014

5. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene.;Zon;J Biol Chem,1991

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