Allogeneic HY antibodies detected 3 months after female-to-male HCT predict chronic GVHD and nonrelapse mortality in humans-Reference-Cited by-同舟云学术

Allogeneic HY antibodies detected 3 months after female-to-male HCT predict chronic GVHD and nonrelapse mortality in humans

Published:2015-05-14 Issue:20 Volume:125 Page:3193-3201
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nakasone Hideki¹,Tian Lu²,Sahaf Bita¹,Kawase Takakazu³,Schoenrock Kelsi¹,Perloff Spenser¹,Ryan Christine E.¹,Paul Jed¹,Popli Rakesh¹,Wu Fang¹,Otani Joanne M.¹,Coller John⁴,Warren Edus H.³,Miklos David B.¹

Affiliation:

1. Division of Blood and Marrow Transplantation, Department of Medicine and

2. Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA;

3. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and

4. Stanford Functional Genomics Facility, Stanford University School of Medicine, Stanford, CA

Abstract

Key Points Detection of multiple HY-Abs at 3 months post-F→M HCT predicts cGVHD incidence, severity, and nonrelapse mortality. Patients with a high HY score may be good candidates for cGVHD prevention trials, especially those targeting allogeneic B cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/20/3193/1386170/3193.pdf

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