Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor–expressing T cells-Reference-Cited by-同舟云学术

Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor–expressing T cells

Published:2015-05-28 Issue:22 Volume:125 Page:3466-3476
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lynn Rachel C.¹,Poussin Mathilde¹,Kalota Anna²,Feng Yang³,Low Philip S.⁴,Dimitrov Dimiter S.³,Powell Daniel J.¹⁵

Affiliation:

1. Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, and

2. Division of Hematology/Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA;

3. Protein Interactions Section, Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD;

4. Department of Chemistry, Purdue University, West Lafayette, IN; and

5. Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Abstract

Key PointsHuman FRβ-specific CAR T cells target AML in vitro and in vivo without toxicity against healthy bone marrow HSCs. Combination with ATRA-mediated receptor upregulation may augment FRβ-directed CAR therapy of AML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/22/3466/1386516/3466.pdf

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