Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs-Reference-Cited by-同舟云学术

Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs

Published:2015-05-14 Issue:20 Volume:125 Page:3202-3212
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Njock Makon-Sébastien¹²³,Cheng Henry S.¹²³,Dang Lan T.¹²³,Nazari-Jahantigh Maliheh⁴,Lau Andrew C.¹²³,Boudreau Emilie¹²³,Roufaiel Mark¹²³,Cybulsky Myron I.¹²³,Schober Andreas⁴⁵,Fish Jason E.¹²³

Affiliation:

1. Toronto General Research Institute, University Health Network, Toronto, ON, Canada;

2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;

3. Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, ON, Canada;

4. Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany; and

5. DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany

Abstract

Key Points Quiescent endothelial cells secrete extracellular vesicles that can be taken up by monocytes to suppress their activation. MiR-10a is transferred to monocytic cells and inhibits the activation of the proinflammatory nuclear factor κB pathway.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/20/3202/1386369/3202.pdf

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