RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation-Reference-Cited by-同舟云学术

RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation

Published:2015-06-04 Issue:23 Volume:125 Page:3570-3579
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kuvardina Olga N.¹,Herglotz Julia²,Kolodziej Stephan¹,Kohrs Nicole¹,Herkt Stefanie¹,Wojcik Bartosch³,Oellerich Thomas³⁴⁵,Corso Jasmin⁶,Behrens Kira²,Kumar Ashok¹,Hussong Helge¹,Urlaub Henning⁶,Koch Joachim¹,Serve Hubert³⁴⁵,Bonig Halvard⁷,Stocking Carol²,Rieger Michael A.³⁴⁵⁸,Lausen Jörn¹

Affiliation:

1. Georg-Speyer Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany;

2. Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany;

3. Department of Medicine, Hematology/Oncology, Johann-Wolfgang-Goethe University, Frankfurt am Main, Germany;

4. German Cancer Consortium, Heidelberg, Germany;

5. German Cancer Research Center, Heidelberg, Germany;

6. Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany;

7. German Red Cross Blood Service and Institute for Transfusion Medicine and Immunohematology, Johann-Wolfgang-Goethe University, Frankfurt am Main, Germany; and

8. LOEWE Center for Cell and Gene Therapy, Frankfurt, Germany

Abstract

Key Points RUNX1 inhibits erythroid differentiation by downregulation of the erythroid gene expression program. RUNX1 can act as an activator and repressor during megakaryocytic differentiation and counteracts the activity of TAL1.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/23/3570/1387971/3570.pdf

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